BDBM653284 1-(6-(4-(5-chloro-1,6- dimethyl-1H-indazol-7- yl)-3-fluoro-7,7- dimethyl-7,8-dihydro- 5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-55::US20240059703, Example 14-78::US20240059703, Example 14-79

SMILES Cc1c(Cl)cc2cnn(C)c2c1-c1c(F)c(nc2CC(C)(C)OCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=VXRKIEYUBHEILE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653284   

LigandPNGBDBM653284(US20240059703, Example 14-78 | 1-(6-(4-(5-chloro-1...)
Affinity DataIC50: 23nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653284(US20240059703, Example 14-78 | 1-(6-(4-(5-chloro-1...)
Affinity DataIC50: 209nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653284(US20240059703, Example 14-78 | 1-(6-(4-(5-chloro-1...)
Affinity DataIC50: 9.60E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent