BDBM653320 4-(5-chloro-6-methyl- 1H-indazol-7-yl)-7,7- dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6- yl)-7,8-dihydro-5H- pyrano[4,3-b]pyridine-3- carbonitrile::US20240059703, Example 14-91

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5c(C)c(Cl)cc6cn[nH]c56)c3C#N)COC(C)(C)C4)C2)C1

InChI Key InChIKey=IYIQAOAUUMONJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653320   

LigandChemical structure of BindingDB Monomer ID 653320BDBM653320(US20240059703, Example 14-91 | 4-(5-chloro-6-methy...)
Affinity DataIC50: 16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent