BDBM653439 4-(2-chloro-5- hydroxyphenyl)-7-(4- methyl-1,3-thiazol-5- yl)-2-(2-(2-propenoyl)- 2,6- diazaspiro[3.4]octan-6- yl)-5,6,7,8-tetrahydro- 1,7-naphthyridine-3- carbonitrile::US20240059703, Example 21-13::US20240059703, Example 21-24::US20240059703, Example 21-25

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5cc(O)ccc5Cl)c3C#N)CCN(c3scnc3C)C4)C2)C1

InChI Key InChIKey=NMPVGAUMZBKOJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653439   

LigandChemical structure of BindingDB Monomer ID 653439BDBM653439(US20240059703, Example 21-13 | US20240059703, Exam...)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653439BDBM653439(US20240059703, Example 21-13 | US20240059703, Exam...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653439BDBM653439(US20240059703, Example 21-13 | US20240059703, Exam...)
Affinity DataIC50: 3.27E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent