BDBM653713 US11912663, Compound IIIb-21

SMILES COc1cc2nccc(Oc3c(F)cc(NC(=O)NC4CC4)c(Cl)c3F)c2cc1C(=O)NC[C@@H](O)CO

InChI Key InChIKey=VVEWWOOATHIBFT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 653713   

TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653713(US11912663, Compound IIIb-21)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653713(US11912663, Compound IIIb-21)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653713(US11912663, Compound IIIb-21)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653713(US11912663, Compound IIIb-21)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653713(US11912663, Compound IIIb-21)
Affinity DataIC50: 75nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent