BDBM653715 US11912663, Compound IIIb-50

SMILES COc1cc2nccc(Oc3c(F)cc(NC(=O)NC4CC4)c(Cl)c3F)c2cc1C(=O)NCCC#N

InChI Key InChIKey=ICXWHKAGMFFTPX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 653715   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 50nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM653715(US11912663, Compound IIIb-50)
Affinity DataIC50: 3.00E+4nMAssay Description:Stabilized cells were dropped onto circular slides and placed in a culture dish with a cell density below 50% and incubated overnight. Cells for expe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent