BDBM653724 5-chloro-N-(2-fluoro-3-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)-2-methoxypyridine-3-sulfonamide::US11912668, Example 3

SMILES CNc1ncc2cc(c(C)nc2n1)-c1cccc(NS(=O)(=O)c2cc(Cl)cnc2OC)c1F

InChI Key InChIKey=YDTBFUITLOWBME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 653724   

TargetEukaryotic translation initiation factor 2-alpha kinase 3 [563-1115](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM653724(5-chloro-N-(2-fluoro-3-(7-methyl-2-(methylamino)py...)
Affinity DataIC50: 100nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM653724(5-chloro-N-(2-fluoro-3-(7-methyl-2-(methylamino)py...)
Affinity DataIC50: 100nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent