BDBM653822 US11912668, Example 102

SMILES CNc1ncc2cc(c(NC)nc2n1)-c1cccc(NS(=O)(=O)c2cc(Cl)cc(C(=O)OC)c2Cl)c1F

InChI Key InChIKey=IQMKCRGYAXPNHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 653822   

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM653822(US11912668, Example 102)
Affinity DataIC50: 100nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3 [563-1115](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM653822(US11912668, Example 102)
Affinity DataIC50: 300nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent