BDBM654413 2-isopropoxy-5-(3-(1-isopropyl-1H- benzo[d][1,2,3]triazol-5-yl)-1,2,4- oxadiazol-5-yl)benzonitrile::US11912693, Compound 22

SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc2n(nnc2c1)C(C)C

InChI Key InChIKey=HRMISELGNYLSHI-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 654413   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654413(US11912693, Compound 22 | 2-isopropoxy-5-(3-(1-iso...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654413(US11912693, Compound 22 | 2-isopropoxy-5-(3-(1-iso...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Trevena

US Patent
LigandPNGBDBM654413(US11912693, Compound 22 | 2-isopropoxy-5-(3-(1-iso...)
Affinity DataEC50: <1.00E+4nMAssay Description:S1P2 Agonist-promoted G-protein responses were determined by measuring changes in intracellular inositol monophosphate using the IP-one TB kit (CisBi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Trevena

US Patent
LigandPNGBDBM654413(US11912693, Compound 22 | 2-isopropoxy-5-(3-(1-iso...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Trevena

US Patent
LigandPNGBDBM654413(US11912693, Compound 22 | 2-isopropoxy-5-(3-(1-iso...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent