BDBM654829 2-(isopropylamino)-5-(3-(1-oxo- 1,2,3,4-tetrahydroisoquinolin-6-yl)- 1,2,4-oxadiazol-5-yl)benzonitrile::US11912693, Compound 442

SMILES CC(C)Nc1ccc(cc1C#N)-c1nc(no1)-c1ccc2C(=O)NCCc2c1

InChI Key InChIKey=XEOWVQUCGPNLFR-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 654829   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654829(US11912693, Compound 442 | 2-(isopropylamino)-5-(3...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654829(US11912693, Compound 442 | 2-(isopropylamino)-5-(3...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent