BDBM654831 2-((cyclopropylmethyl)amino)-5-(3- (2,2-diethyl-4-oxochroman-6-yl)- 1,2,4-oxadiazol-5-yl)benzonitrile::US11912693, Compound 444

SMILES CC1(C)CC(=O)c2cc(ccc2O1)-c1noc(n1)-c1ccc(NCC2CC2)c(c1)C#N

InChI Key InChIKey=PLEHFHUNGNCIQE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 654831   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654831(US11912693, Compound 444 | 2-((cyclopropylmethyl)a...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654831(US11912693, Compound 444 | 2-((cyclopropylmethyl)a...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent