BDBM654844 4-[1-(propan-2-yl)-1H-1,2,3- benzotriazol-5-yl]-5-oxa-10-thia-3- azatricyclo[7.3.0.02,6]dodeca- 1(9),2(6),3,7,11-pentaene::US11912693, Compound 457

SMILES CC(C)n1nnc2cc(ccc12)-c1nc2c(ccc3sccc23)o1

InChI Key InChIKey=DAPIEXGZTVBZNE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 654844   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654844(US11912693, Compound 457 | 4-[1-(propan-2-yl)-1H-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654844(US11912693, Compound 457 | 4-[1-(propan-2-yl)-1H-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent