BDBM654864 2-[(2,2-difluoroethyl)amino]-5-[5-(2- oxo-1,2,3,4-tetrahydroquinolin-6-yl)- 1,3,4-oxadiazol-2-yl]benzonitrile::US11912693, Compound 477

SMILES FC(F)CNc1ccc(cc1C#N)-c1nnc(o1)-c1ccc2NC(=O)CCc2c1

InChI Key InChIKey=KVRZKRZAPSEMMP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 654864   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654864(US11912693, Compound 477 | 2-[(2,2-difluoroethyl)a...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654864(US11912693, Compound 477 | 2-[(2,2-difluoroethyl)a...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent