BDBM65502 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one::8-Br-cGMP

SMILES Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1

InChI Key InChIKey=YUFCOOWNNHGGOD-UMMCILCDSA-N

Data  8 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 65502   

TargetIsoform Beta of cGMP-dependent protein kinase 1 [1-351](Human)
Baylor College of Medicine

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  222nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  765nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50: <2nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcGMP-dependent protein kinase 2 [41-418,G356E](Human)
Baylor College of Medicine

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  30nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcGMP-dependent protein kinase 2(Human)
Baylor College of Medicine

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  58nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcGMP-dependent protein kinase 2 [41-418](Human)
Baylor College of Medicine

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  20nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcGMP-dependent protein kinase 2 [41-418,G232E](Human)
Baylor College of Medicine

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  11nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM65502(2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydrox...)
Affinity DataEC50:  206nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)