BDBM656321 N-(2-Phenyl-1,3-benzoxazol-6-yl)-N′-[(pyridin-4-yl)methyl]urea::US11918568, Example 2

SMILES O=C(NCc1ccncc1)Nc1ccc2nc(oc2c1)-c1ccccc1

InChI Key InChIKey=UUEQAVONCDUZBA-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 656321   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM656321(N-(2-Phenyl-1,3-benzoxazol-6-yl)-N′-[(pyridi...)
Affinity DataEC50:  48nMAssay Description:Inhibition of NAMPT (unknown origin) using NAM and PRPP as substrates incubated for 2 hrs in presence of ATP by fluorimetric plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM656321(N-(2-Phenyl-1,3-benzoxazol-6-yl)-N′-[(pyridi...)
Affinity DataEC50:  50nMAssay Description:Activation of N-terminal His-tagged human NAMPT expressed in Escherichia coli BL 21 (DE3) using NAM and PRPP as substrates incubated for 15 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM656321(N-(2-Phenyl-1,3-benzoxazol-6-yl)-N′-[(pyridi...)
Affinity DataEC50:  50nMAssay Description:The NAMPT enzyme assay was conducted in accordance with the method of Formentini et al. (Formentini L. et al., Biochemical Pharmacology 77 (2009) 161...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent