BDBM656613 US11919901, Compound 17::tert-butyl ((3R,6S)-6-((2-(5-(2- (cyclopropyl(isopropyl)carbamoyl)-4- fluorophenoxy)pyrimidin-4-yl)-2,7- diazaspiro[3.5]nonan-7-yl)methyl)tetrahydro-2H- pyran-3-yl)carbamate

SMILES CC(C)N(C1CC1)C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NC(=O)OC(C)(C)C)CC2

InChI Key InChIKey=AUOUIICKWATATC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 656613   

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Syndax Pharmaceuticals

US Patent
LigandPNGBDBM656613(tert-butyl ((3R,6S)-6-((2-(5-(2- (cyclopropyl(isop...)
Affinity DataKi: <1nMAssay Description:Table 4: For Ki determination, individual compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent

TargetMenin(Human)
Syndax Pharmaceuticals

US Patent
LigandPNGBDBM656613(tert-butyl ((3R,6S)-6-((2-(5-(2- (cyclopropyl(isop...)
Affinity DataIC50: 100nMAssay Description:For IC50 determination test compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system. Lower sub-sto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent