BDBM657644 N-[1-(5-{4-chloro-2-[(dimethylamino)methyl]phenyl}thiophen-2-yl)ethyl]-6,7-dimethoxy-2-methylquinazolin-4-amine::US20240083857, Example 323
SMILES COc1cc2nc(C)nc(NC(C)c3ccc(s3)-c3ccc(Cl)cc3CN(C)C)c2cc1OC
InChI Key InChIKey=XBQLOJBAWLTGJZ-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 657644
Affinity DataIC50: 39.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
Affinity DataIC50: 66.4nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
Affinity DataIC50: 72.9nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair