BDBM658050 US20240083897, Compound 3

SMILES CNC(=O)c1ncn2cc(ncc12)-c1c(F)ccc(NS(=O)(=O)c2cc(Cl)cnc2OC)c1F

InChI Key InChIKey=KIGXQRBUVDDSPP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 658050   

TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 12nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 47nMAssay Description:Inhibition of ZAK in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataEC50:  72nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 77nMAssay Description:Inhibition of GCN2 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of RIPK2 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of MAP2K5 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of PIK3C2B in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PEK in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of RIPK3 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Nek1(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of NEK1 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed