BDBM658051 2-[3-(5-Chloro-2-methoxypyridine-3-sulfonamido)-2,6-difluorophenyl]-N-methylimidazo[1,5-b]pyridazine-5-carboxamide ::US20240083897, Compound 4
SMILES CNC(=O)c1ncn2nc(ccc12)-c1c(F)ccc(NS(=O)(=O)c2cc(Cl)cnc2OC)c1F
InChI Key InChIKey=DEMIJBHEBVXGEO-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 658051
Affinity DataIC50: 14nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Pharmaron UK Ltd.
Curated by ChEMBL
Pharmaron UK Ltd.
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair