BDBM658053 6-[2,6-difluoro-3-(5-fluoro-2-methylpyridine-3-sulfonamido)phenyl]-N-methylimidazo[1,5-a]pyridine-1-carboxamide ::US20240083897, Compound 6
SMILES CNC(=O)c1ncn2cc(ccc12)-c1c(F)ccc(NS(=O)(=O)c2cc(F)cnc2C)c1F
InChI Key InChIKey=XZDFGGGCYBDMFZ-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 658053
Affinity DataIC50: 39nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
Affinity DataEC50: 460nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Pharmaron UK Ltd.
Curated by ChEMBL
Pharmaron UK Ltd.
Curated by ChEMBL
Affinity DataEC50: 5.80E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair