BDBM658420 US20240083900, Example 29

SMILES Cn1cc(cn1)-c1cn2nccc2c(O[C@@H]2CCCN(CC2)C(=O)C=C)n1

InChI Key InChIKey=BWAGOPAZDUZUSQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 658420   

LigandPNGBDBM658420(US20240083900, Example 29)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) using fluorescein labeled polyGAT peptide substrate incubated for 30 mins in presence of ATP by time-resolved fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM658420(US20240083900, Example 29)
Affinity DataKd:  0.600nMAssay Description:Inhibition of human full-length wild type BTK (M1 to S659 residues) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM658420(US20240083900, Example 29)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

LigandPNGBDBM658420(US20240083900, Example 29)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BTK in human Ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed