BDBM658433 US20240083900, Example 79
SMILES CN([C@H]1C[C@](C)(C1)Oc1nc(cn2nccc12)-c1cnn(C)c1)C(=O)C=C
InChI Key InChIKey=WBFSPPPOPIJCLF-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 658433
Affinity DataKd: 0.630nMAssay Description:Inhibition of human full-length wild type BTK (M1 to S659 residues) expressed in mammalian expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2(Human)
Biogen Research and Development
Curated by ChEMBL
Biogen Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PLCgamma2 phosphorylation in anti-IgM activated human Ramos cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of BTK in human TMD8 cells assessed as reduction in CD36 expressionMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of BTK in human TMD8 cells assessed as reduction in CD19 expressionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Biogen Research and Development
Curated by ChEMBL
Biogen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CaV1.2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Human)
Biogen Research and Development
Curated by ChEMBL
Biogen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV1.5 (unknown origin)More data for this Ligand-Target Pair