BDBM658458 N-methyl-N-((cis)-3-((6-(1-((R)-tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide and N-methyl-N-((cis)-3-((6-(1-((S)-tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide::US20240083900, Example 155

SMILES C=CC(=O)N(C)[C@H]1C[C@@H](Oc2nc(-c3cnn([C@@H]4CCOC4)c3)cn3nccc23)C1

InChI Key InChIKey=YMIPEAYSFUOIKJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 658458   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandChemical structure of BindingDB Monomer ID 658458BDBM658458(US20240083900, Example 155 | N-methyl-N-((cis)-3-(...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent