BDBM659318 2-(1-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)quinazolin-8-yl)azetidin-3-yl)acetonitrile::US20240092761, Compound 14

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2cccc(N3CC(CC#N)C3)c2n1

InChI Key InChIKey=RSZXVGWSALOIGV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 659318   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659318(2-(1-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)q...)
Affinity DataIC50: 200nMAssay Description:In a CHEF assay, phosphorylation of a peptide substrate results in proportional increase in fluorescence. CHEF kinase assay use peptide substrates co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659318(2-(1-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)q...)
Affinity DataIC50: 200nMAssay Description:CDK4/Cyclin D1 catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the substrate peptide 5-FAM-Dyrktide (5-FAM-RRRFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659318(2-(1-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)q...)
Affinity DataIC50: 200nMAssay Description:ADP-Glo is performed in 2 steps upon completion of kinase reaction: a combined termination of kinase reaction and depletion of remaining ATP in the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659318(2-(1-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)q...)
Affinity DataIC50: 350nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced and is correlated with the kinase activity. CDK1/Cyclin B1 was pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent