BDBM659327 8-(7-(methylsulfonyl)-2,7- diazaspiro[4.4]nonan-2- yl)-N-(1- (methylsulfonyl)piperidin- 4-yl)quinazolin-2-amine::US20240092761, Compound 23
SMILES CS(=O)(=O)N1CCC2(CCN(C2)c2cccc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc23)C1
InChI Key InChIKey=NAJRJQAJYKIILR-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 659327
Affinity DataIC50: 2.00E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced and is correlated with the kinase activity. CDK1/Cyclin B1 was pur...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:ADP-Glo is performed in 2 steps upon completion of kinase reaction: a combined termination of kinase reaction and depletion of remaining ATP in the f...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:CDK4/Cyclin D1 catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the substrate peptide 5-FAM-Dyrktide (5-FAM-RRRFR...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:In a CHEF assay, phosphorylation of a peptide substrate results in proportional increase in fluorescence. CHEF kinase assay use peptide substrates co...More data for this Ligand-Target Pair