BDBM659343 8-(6-(2-methoxyethyl)- 2,6-diazaspiro[3.4]octan- 2-yl)-N-(1- (methylsulfonyl)piperidin- 4-yl)quinazolin-2-amine::US20240092761, Compound 39

SMILES COCCN1CCC2(CN(C2)c2cccc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc23)C1

InChI Key InChIKey=NJWISXLOSILPQV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 659343   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659343(8-(6-(2-methoxyethyl)- 2,6-diazaspiro[3.4]octan- 2...)
Affinity DataIC50: 200nMAssay Description:CDK4/Cyclin D1 catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the substrate peptide 5-FAM-Dyrktide (5-FAM-RRRFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659343(8-(6-(2-methoxyethyl)- 2,6-diazaspiro[3.4]octan- 2...)
Affinity DataIC50: 200nMAssay Description:ADP-Glo is performed in 2 steps upon completion of kinase reaction: a combined termination of kinase reaction and depletion of remaining ATP in the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659343(8-(6-(2-methoxyethyl)- 2,6-diazaspiro[3.4]octan- 2...)
Affinity DataIC50: 1.25E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced and is correlated with the kinase activity. CDK1/Cyclin B1 was pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659343(8-(6-(2-methoxyethyl)- 2,6-diazaspiro[3.4]octan- 2...)
Affinity DataIC50: 1.25E+3nMAssay Description:In a CHEF assay, phosphorylation of a peptide substrate results in proportional increase in fluorescence. CHEF kinase assay use peptide substrates co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent