BDBM660574 US20240092803, Example 3

SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1C2CCC1CNC2)c1cccc2cccc(Cl)c12

InChI Key InChIKey=RBXOKWWBMGILFR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 660574   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Beigene Switzerland

US Patent
LigandPNGBDBM660574(US20240092803, Example 3)
Affinity DataIC50: 635nMAssay Description:This assay was used to identify compounds which competitively interact with the binding of KRAS protein to SOS1 in the presence of GDP. GST-tagged WT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Beigene Switzerland

US Patent
LigandPNGBDBM660574(US20240092803, Example 3)
Affinity DataIC50: 5.00E+4nMAssay Description:This assay was used to identify compounds which competitively interact with the binding of KRAS protein to SOS1 in the presence of GDP. GST-tagged WT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent