BDBM661087 (3S)-4-(4-hydroxyphenyl)-3-[5-[[[5-(2-pyridyl)-2-thienyl]sulfonylamino]methyl]triazol-1-yl]butanehydroxamic acid::US20240101542, Compound 33

SMILES ONC(=O)C[C@H](Cc1ccc(O)cc1)n1nncc1CNS(=O)(=O)c1ccc(s1)-c1ccccn1

InChI Key InChIKey=LWNJKRUKVSPFJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 661087   

TargetInterleukin-1 receptor antagonist protein(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM661087(US20240101542, Compound 33 | (3S)-4-(4-hydroxyphen...)
Affinity DataIC50: 84nMAssay Description:Inhibition of IRAP (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEndoplasmic reticulum aminopeptidase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM661087(US20240101542, Compound 33 | (3S)-4-(4-hydroxyphen...)
Affinity DataIC50: 850nMAssay Description:Inhibition of ERAP2 (unknown origin) using R-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEndoplasmic reticulum aminopeptidase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM661087(US20240101542, Compound 33 | (3S)-4-(4-hydroxyphen...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzymatic activity of ERAP1 or 2 was assayed using L-AMC (L-Leucine-7-amido-4-methylcoumarin hydrochloride) or R-AMC (L-Arginine-7-amido-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetEndoplasmic reticulum aminopeptidase 1 (ERAP1)(Human)
Universite De Lille

US Patent
LigandPNGBDBM661087(US20240101542, Compound 33 | (3S)-4-(4-hydroxyphen...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzymatic activity of ERAP1 or 2 was assayed using L-AMC (L-Leucine-7-amido-4-methylcoumarin hydrochloride) or R-AMC (L-Arginine-7-amido-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetEndoplasmic reticulum aminopeptidase 1 (ERAP1)(Human)
Universite De Lille

US Patent
LigandPNGBDBM661087(US20240101542, Compound 33 | (3S)-4-(4-hydroxyphen...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ERAP1 (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed