BDBM662022 2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (diethylamino)cyclohexyl)amino)pyrimidin- 5-yl)vinyl)-6-methylpyridin-2- yl)benzenesulfonamide::US11945784, Compound 30

SMILES CCN(CC)C1CCC(Nc2ncc(/C=C/c3ccc(NS(=O)(=O)c4ccccc4Cl)nc3C)cn2)CC1

InChI Key InChIKey=CXWPLQZHJUUNNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 662022   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandChemical structure of BindingDB Monomer ID 662022BDBM662022(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (diethylamino...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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Date in BDB:
6/17/2024
Entry Details
US Patent