BDBM662039 2-chloro-N-(6-ethyl-5-((E)-2-(2-(((1r,4r)-4- (methylamino)cyclohexyl)amino)pyrimidin- 5-yl)vinyl)pyridin-2-yl)benzenesulfonamide::US11945784, Compound 47

SMILES CCc1nc(NS(=O)(=O)c2ccccc2Cl)ccc1/C=C/c1cnc(NC2CCC(NC)CC2)nc1

InChI Key InChIKey=GEKKZNDFCYNXQJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 662039   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandChemical structure of BindingDB Monomer ID 662039BDBM662039(2-chloro-N-(6-ethyl-5-((E)-2-(2-(((1r,4r)-4- (meth...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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Date in BDB:
6/17/2024
Entry Details
US Patent