BDBM662051 2-chloro-N-(3-fluoro-6-methoxy-5-((E)-2-(2- (((1r,4r)-4- (methylamino)cyclohexyl)amino)pyrimidin- 5-yl)vinyl)pyridin-2-yl)benzenesulfonamide::US11945784, Compound 59

SMILES CNC1CCC(Nc2ncc(/C=C/c3cc(F)c(NS(=O)(=O)c4ccccc4Cl)nc3OC)cn2)CC1

InChI Key InChIKey=IMOGQKNPQOYZQL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 662051   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandChemical structure of BindingDB Monomer ID 662051BDBM662051(2-chloro-N-(3-fluoro-6-methoxy-5-((E)-2-(2- (((1r,...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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Date in BDB:
6/17/2024
Entry Details
US Patent