BDBM662070 8-[(2S,5R)-4-[1-(2,6-difluorophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile::US20240108654, Compound 11

SMILES CC(N1C[C@H](C)N(C[C@H]1C)c1cc(=O)n(C)c2ccc(nc12)C#N)c1c(F)cccc1F

InChI Key InChIKey=JSDWTOGDZIDOQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662070   

TargetDiacylglycerol kinase alpha(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM662070(8-[(2S,5R)-4-[1-(2,6-difluorophenyl)ethyl]-2,5-dim...)
Affinity DataIC50: 140nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM662070(8-[(2S,5R)-4-[1-(2,6-difluorophenyl)ethyl]-2,5-dim...)
Affinity DataIC50: 570nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent