BDBM662168 1-((2-((2- aminoethyl)amino)pyri- midin-5-yl)methyl)-3- (4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A081::US20240226094, Compound A081

SMILES CC(C)(c1csc(NC(=O)NCc2cnc(NCCN)nc2)n1)c1ccc(Br)cc1

InChI Key InChIKey=QLCJIVVCLCJYBD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662168   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662168(1-((2-((2- aminoethyl)amino)pyri- midin-5-yl)methy...)
Affinity DataIC50: 17nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662168(1-((2-((2- aminoethyl)amino)pyri- midin-5-yl)methy...)
Affinity DataIC50: 17nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662168(1-((2-((2- aminoethyl)amino)pyri- midin-5-yl)methy...)
Affinity DataIC50: 17nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent