BDBM662179 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6- (piperazin-1-yl)pyridin- 3-yl)methyl)urea::US20240109853, Compound A092::US20240226094, Compound A092

SMILES CC(C)(c1csc(NC(=O)NCc2ccc(nc2)N2CCNCC2)n1)c1ccc(Br)cc1

InChI Key InChIKey=KEDDALKEZYEJKX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662179   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662179(1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)...)
Affinity DataIC50: 20nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662179(1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)...)
Affinity DataIC50: 20nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662179(1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)...)
Affinity DataIC50: 20nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent