BDBM662202 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N-(1- propylpiperidin-4- yl)picolinamide::US20240109853, Compound A115::US20240226094, Compound A115

SMILES CCCN1CCC(CC1)NC(=O)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)cn1

InChI Key InChIKey=ZEMOPPAGSWXSDA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662202   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662202(5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol...)
Affinity DataIC50: 19nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662202(5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol...)
Affinity DataIC50: 19nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662202(5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol...)
Affinity DataIC50: 19nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent