BDBM662247 (S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A160::US20240226094, Compound A160::US20250381196, Compound A160

SMILES C[C@@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Br)cc1

InChI Key InChIKey=VKXUGYUEQJOCJY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662247   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 662247BDBM662247((S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol...)
Affinity DataIC50: 10nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 662247BDBM662247((S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol...)
Affinity DataIC50: 10nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2026
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 662247BDBM662247((S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol...)
Affinity DataIC50: 10nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent