BDBM662258 1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A171::US20240226094, Compound A171

SMILES COc1ccc(cc1)C(C)(C#C)c1csc(NC(N)=O)n1

InChI Key InChIKey=WWLSVGXVGZGYSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662258   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662258(1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2...)
Affinity DataIC50: 16nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662258(1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2...)
Affinity DataIC50: 16nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662258(1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2...)
Affinity DataIC50: 16nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent