BDBM662323 N-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A236::US20240226094, Compound A236

SMILES Fc1cc(ccc1N1CCNCC1)C1CN(C1)C(=O)Nc1nc(cs1)C1(CCCC1)c1ccc(Br)cc1

InChI Key InChIKey=QFCBQYKBEOKLJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662323   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662323(N-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl...)
Affinity DataIC50: 13nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662323(N-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl...)
Affinity DataIC50: 13nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662323(N-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl...)
Affinity DataIC50: 13nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent