BDBM662477 N-[4-[1-(4-fluorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240109853, Compound B069::US20240109853, Compound B071::US20240226094, Compound B071

SMILES C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2CO)n1)c1ccc(F)cc1

InChI Key InChIKey=OIWGOIUEDIIJFF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 662477   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 20nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 20nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 20nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 60nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 60nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662477(US20240109853, Compound B069 | US20240109853, Comp...)
Affinity DataIC50: 60nMAssay Description:In brief, dose-response studies were performed in 384-well assay plates. Each well contained 0.1 mg TIFA, ALPK1 (2 nM final concentration in reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent