BDBM662547 2,6-difluoro-N-[4-[1- (4-methoxyphenyl)-1- methyl-prop-2- ynyl]thiazol-2-yl]-4- piperazin-1-yl- benzamide::US20240109853, Compound C036::US20240109853, Compound C048::US20240226094, Compound C048

SMILES COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1

InChI Key InChIKey=NWVLNCVDYNKJJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 662547   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662547(US20240109853, Compound C036 | 2,6-difluoro-N-[4-[...)
Affinity DataIC50: 16nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662547(US20240109853, Compound C036 | 2,6-difluoro-N-[4-[...)
Affinity DataIC50: 16nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662547(US20240109853, Compound C036 | 2,6-difluoro-N-[4-[...)
Affinity DataIC50: 67nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662547(US20240109853, Compound C036 | 2,6-difluoro-N-[4-[...)
Affinity DataIC50: 67nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent