BDBM662586 1-[4-[5-[5-[(1R)-1- (3,5-dichloro-4- pyridyl)ethoxy]-1H- indazol-3-yl]-2- pyridyl]piperazin-1- yl]propan-1-one::US20240109865, Example 9.

SMILES CCC(=O)N1CCN(CC1)c1ccc(cn1)-c1n[nH]c2ccc(O[C@H](C)c3c(Cl)cncc3Cl)cc12

InChI Key InChIKey=GLZNCFDNVKZJNN-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 662586   

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandPNGBDBM662586(US20240109865, Example 9. | 1-[4-[5-[5-[(1R)-1- (3...)
Affinity DataIC50: 314nMAssay Description:Inhibition of recombinant TEL/VEGFR2 (unknown origin) transduced in mouse BaF3 cells incubated for 48 hrs by Cell Titer Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed