BDBM662623 US20240109865, Example 46.

SMILES C[C@@H](Oc1ccc2[nH]nc(-c3ccc(nc3)N3CC4(C3)CN(C4)S(C)(=O)=O)c2c1)c1c(Cl)cncc1Cl

InChI Key InChIKey=JOAFWIHZEBKYQK-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 662623   

LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FGFR3 V555L mutant (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild-type FGFR3 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 2nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human FLT4 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of FGFR3 K650E mutant (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 7nMAssay Description:Inhibition of human FGFR2 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FGFR4 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 21nMAssay Description:Inhibition of wild-type FGFR3 (unknown origin) by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 21nMAssay Description:Inhibition of FGFR3 G380R mutant (unknown origin) by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 36nMAssay Description:Inhibition of human JAK2 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 65nMAssay Description:Inhibition of human LTK by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 73nMAssay Description:Inhibition of FGFR3 N540K mutant (unknown origin) by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR1 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 201nMAssay Description:Inhibition of human FLT1 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 206nMAssay Description:Inhibition of human JAK3 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 325nMAssay Description:Inhibition of human VEGFR2 by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed