BDBM662784 5-[(1R)-1-(3,5-dichloro-2- methyl-4-pyridyl)ethoxy]-6- methoxy-3-[6-(2- methylsulfonyl-2,6- diazaspiro[3.3]heptan-6-yl)-3- pyridyl]-1H-indazole::US20240109865, Example 207.

SMILES COc1cc2[nH]nc(-c3ccc(nc3)N3CC4(C3)CN(C4)S(C)(=O)=O)c2cc1O[C@H](C)c1c(Cl)cnc(C)c1Cl

InChI Key InChIKey=KNMRABBRUUSJLH-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 662784   

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662784BDBM662784(US20240109865, Example 207. | 5-[(1R)-1-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662784BDBM662784(US20240109865, Example 207. | 5-[(1R)-1-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662784BDBM662784(US20240109865, Example 207. | 5-[(1R)-1-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662784BDBM662784(US20240109865, Example 207. | 5-[(1R)-1-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662784BDBM662784(US20240109865, Example 207. | 5-[(1R)-1-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent