BDBM662794 (R)-5-(5-(1-(3,5- dimethylpyridazin-4- yl)ethoxy)-6-methoxy-1H- indazol-3-yl)-2-(2-oxa-6- azaspiro[3.3]heptan-6- yl)nicotinonitrile::US20240109865, Example 218.::US20240109865, Example 324.

SMILES COc1cc2[nH]nc(-c3cnc(N4CC5(COC5)C4)c(c3)C#N)c2cc1O[C@H](C)c1c(C)cnnc1C

InChI Key InChIKey=MWZPSBXSLINPHN-UHFFFAOYSA-N

Data  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 662794   

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662794BDBM662794(US20240109865, Example 218. | (R)-5-(5-(1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent