BDBM662888 5-(5-((R)-1-(3,5- dimethylpyridazin-4- yl)ethoxy)-6-methoxy-1H- indazol-3-yl)-2-((R)-3-(2- hydroxypropan-2-yl)pyrrolidin- 1-yl)nicotinonitrile::US20240109865, Example 321.

SMILES COc1cc2[nH]nc(-c3cnc(N4CC[C@H](C4)C(C)(C)O)c(c3)C#N)c2cc1O[C@H](C)c1c(C)cnnc1C

InChI Key InChIKey=VMMIMVUCRWGVTP-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 662888   

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662888BDBM662888(US20240109865, Example 321. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662888BDBM662888(US20240109865, Example 321. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662888BDBM662888(US20240109865, Example 321. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662888BDBM662888(US20240109865, Example 321. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662888BDBM662888(US20240109865, Example 321. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent