BDBM662898 5-(5-((R)-1-(3,5- dichloropyridin-4-yl)ethoxy)- 1H-indazol-3-yl)-2-(6-hydroxy- 3-azabicyclo[3.1.0]hexan-3- yl)nicotinonitrile::US20240109865, Example 331.

SMILES C[C@@H](Oc1ccc2[nH]nc(-c3cnc(N4CC5C(O)C5C4)c(c3)C#N)c2c1)c1c(Cl)cncc1Cl

InChI Key InChIKey=OUEAOPJBPNGFPG-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 662898   

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662898BDBM662898(US20240109865, Example 331. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662898BDBM662898(US20240109865, Example 331. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662898BDBM662898(US20240109865, Example 331. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662898BDBM662898(US20240109865, Example 331. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  200nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 662898BDBM662898(US20240109865, Example 331. | 5-(5-((R)-1-(3,5- di...)
Affinity DataKd:  200nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent