BDBM664333 (S)-2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)-N- (2-methyl-5-(2-(2- methylpyrrolidin-1- yl)acetamido)pyridin-3- yl)pyrazolo[5,1-b]thiazole-7- carboxamide::US20240109917, Example 416

SMILES C[C@H]1CCCN1CC(=O)Nc1cnc(C)c(NC(=O)c2cnn3cc(sc23)-c2cnn3CCCc23)c1

InChI Key InChIKey=GZFWYRWGUBETFM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 664333   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664333((S)-2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664333((S)-2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)...)
Affinity DataIC50: 1.60nMAssay Description:Stock Solutions:Assay buffer stock contains 50 mM HEPES pH7.5, 10 mM MgCl2, 0.01% Brij-35, 1 mM EGTA.Tb-labeled inactive PDGFRβ. 3.6 μM in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664333((S)-2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)...)
Affinity DataIC50: 7.50E+3nMAssay Description:Assay Procedure:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent