BDBM664351 2-(1,5-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(3,3- dimethylazetidin-1- yl)acetamido)-2-methylpyridin- 3-yl)pyrazolo[5,1-b]thiazole-7- carboxamide::US20240109917, Example 434

SMILES Cc1c(cnn1C)-c1cn2ncc(C(=O)Nc3cc(NC(=O)CN4CC(C)(C)C4)cnc3C)c2s1

InChI Key InChIKey=NREDXODJCFTBBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 664351   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664351(2-(1,5-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(3,3- di...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664351(2-(1,5-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(3,3- di...)
Affinity DataIC50: 2.20nMAssay Description:Stock Solutions:Assay buffer stock contains 50 mM HEPES pH7.5, 10 mM MgCl2, 0.01% Brij-35, 1 mM EGTA.Tb-labeled inactive PDGFRβ. 3.6 μM in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664351(2-(1,5-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(3,3- di...)
Affinity DataIC50: 5.22E+3nMAssay Description:Assay Procedure:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent