BDBM664361 2-(1,3-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(2,2- dimethylpyrrolidin-1- yl)acetamido)-2-methylpyridin- 3-yl)pyrazolo[5,1-b]thiazole-7- carboxamide::US20240109917, Example 444

SMILES Cc1nn(C)cc1-c1cn2ncc(C(=O)Nc3cc(NC(=O)CN4CCCC4(C)C)cnc3C)c2s1

InChI Key InChIKey=UOFVBNKNBSKQNW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 664361   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664361(2-(1,3-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(2,2- di...)
Affinity DataIC50:  0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664361(2-(1,3-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(2,2- di...)
Affinity DataIC50: >7.50E+3nMAssay Description:Assay Procedure:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664361(2-(1,3-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(2,2- di...)
Affinity DataIC50:  1.80nMAssay Description:Stock Solutions:Assay buffer stock contains 50 mM HEPES pH7.5, 10 mM MgCl2, 0.01% Brij-35, 1 mM EGTA.Tb-labeled inactive PDGFRβ. 3.6 μM in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent