BDBM664694 US11952377, Example 22

SMILES Cn1c2cnc(nc2c(Nc2ccc(cc2)C#N)cc1=O)-n1ccnc1

InChI Key InChIKey=HKHMLJDGFKAXTI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 664694   

TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM664694(US11952377, Example 22)
Affinity DataIC50: 10nMAssay Description:The CD38 enzyme assay was performed as described previously (Becherer, J D, et al. J. Med. Chem. 2015, 58, 7021-7056). Briefly, 200 nL of a dose resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
US Patent