BDBM664710 (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4- oxobutyl)-5,5-difluoropiperidin-2-one (Gemigliptin)::US20240115577, Compound 11

SMILES N[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCc2c(C1)nc(nc2C(F)(F)F)C(F)(F)F

InChI Key InChIKey=ZWPRRQZNBDYKLH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 664710   

TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664710((S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- di...)
Affinity DataIC50: 4.10nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664710((S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- di...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DPP4 expressed in Sf21 cells using Gly-Pro-7-AMC substrate pre-incubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed